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Target
Ras-related C3 botulinum toxin substrate 1
Ligand
BDBM54686
Substrate
n/a
Meas. Tech.
Additional SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac1 wildtype
EC50
30000±n/a nM
Citation
 PubChem, PC Additional SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac1 wildtype PubChem Bioassay (2009)[AID] 
Target
Name:
Ras-related C3 botulinum toxin substrate 1
Synonyms:
RAC1_MOUSE | Rac1 | Rac1 protein
Type:
PROTEIN
Mol. Mass.:
21455.91
Organism:
Mus musculus
Description:
EBI_101485
Residue:
192
Sequence:
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL
  
Inhibitor
Name:
BDBM54686
Synonyms:
2-amino-5-benzoyl-4-(3-bromo-4-methoxy-phenyl)-1-mesyl-pyrrole-3-carbonitrile | 2-amino-5-benzoyl-4-(3-bromo-4-methoxyphenyl)-1-methylsulfonyl-3-pyrrolecarbonitrile | 2-amino-5-benzoyl-4-(3-bromo-4-methoxyphenyl)-1-methylsulfonylpyrrole-3-carbonitrile | 2-azanyl-4-(3-bromanyl-4-methoxy-phenyl)-1-methylsulfonyl-5-(phenylcarbonyl)pyrrole-3-carbonitrile | UNM-0000305776 | cid_25220927
Type:
Small organic molecule
Emp. Form.:
C20H16BrN3O4S
Mol. Mass.:
474.328
SMILES:
COc1ccc(cc1Br)-c1c(C#N)c(N)n(c1C(=O)c1ccccc1)S(C)(=O)=O
Structure:
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