Target
Ras-related protein Rab-7a
Ligand
BDBM54622
Substrate
n/a
Meas. Tech.
Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype
Ki
1470±n/a nM
Citation
 PubChem, PC Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype PubChem Bioassay (2009)[AID] 
Target
Name:
Ras-related protein Rab-7a
Synonyms:
GTP-binding protein (rab7) | RAB7 | RAB7A | RAB7A_CANLF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23519.50
Organism:
Canis lupus familiaris
Description:
gi_164058
Residue:
207
Sequence:
MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRQVATKRAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQETEVELYNEFPEPIKLDKNDRAKTSAESCSC
  
Inhibitor
Name:
BDBM54622
Synonyms:
3-(3,4-dimethoxyphenyl)-2-(3-fluorophenyl)-5-(4-fluorophenyl)-3,4-dihydropyrazole | 5-(3,4-dimethoxyphenyl)-1-(3-fluorophenyl)-3-(4-fluorophenyl)-2-pyrazoline | UNM-0000305861 | cid_2883119
Type:
Small organic molecule
Emp. Form.:
C23H20F2N2O2
Mol. Mass.:
394.4139
SMILES:
COc1ccc(cc1OC)C1CC(=NN1c1cccc(F)c1)c1ccc(F)cc1 |c:13|
Structure:
Search PDB for entries with ligand similarity: