Reaction Details
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GTPase KRas [1-37]
Ligand
BDBM54681
Substrate
n/a
Meas. Tech.
Additional SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras activated mutant
EC50
30000±n/a nM
Comments
Extracted from aid = 2043 and tid = 2
Citation
PubChem, PC Additional SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras activated mutant PubChem Bioassay (2009)[AID] More Info.:
Target
Name:
GTPase KRas [1-37]
Synonyms:
ras protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
4034.04
Organism:
Homo sapiens (Human)
Description:
gi_190938
Residue:
37
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIE
Inhibitor
Name:
BDBM54681
Synonyms:
3-[3-(hydroxyamino)-1H-indol-2-yl]-2-indolone | 3-[3-(hydroxyamino)-1H-indol-2-yl]indol-2-one | 3-[3-(oxidanylamino)-1H-indol-2-yl]indol-2-one | UNM-0000305771 | cid_5326739
Type:
Small organic molecule
Emp. Form.:
C16H11N3O2
Mol. Mass.:
277.2774
SMILES:
ONc1c([nH]c2ccccc12)C1=c2ccccc2=NC1=O |c:13,20|
Structure:
