Reaction Details
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GTPase KRas [1-37]
Ligand
BDBM54688
Substrate
n/a
Meas. Tech.
Additional SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras activated mutant
EC50
30000±n/a nM
Comments
Extracted from aid = 2043 and tid = 2
Citation
PubChem, PC Additional SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras activated mutant PubChem Bioassay (2009)[AID] More Info.:
Target
Name:
GTPase KRas [1-37]
Synonyms:
ras protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
4034.04
Organism:
Homo sapiens (Human)
Description:
gi_190938
Residue:
37
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIE
Inhibitor
Name:
BDBM54688
Synonyms:
2-amino-5-(4-bromobenzoyl)-1-(4-methoxyphenyl)sulfonyl-4-phenyl-pyrrole-3-carbonitrile | 2-amino-5-(4-bromobenzoyl)-1-(4-methoxyphenyl)sulfonyl-4-phenylpyrrole-3-carbonitrile | 2-amino-5-[(4-bromophenyl)-oxomethyl]-1-(4-methoxyphenyl)sulfonyl-4-phenyl-3-pyrrolecarbonitrile | 2-azanyl-5-(4-bromophenyl)carbonyl-1-(4-methoxyphenyl)sulfonyl-4-phenyl-pyrrole-3-carbonitrile | UNM-0000305778 | cid_25220929
Type:
Small organic molecule
Emp. Form.:
C25H18BrN3O4S
Mol. Mass.:
536.397
SMILES:
COc1ccc(cc1)S(=O)(=O)n1c(N)c(C#N)c(c1C(=O)c1ccc(Br)cc1)-c1ccccc1
Structure:
