Reaction Details
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Ras-related protein Rab-2A
Ligand
BDBM54656
Substrate
n/a
Meas. Tech.
Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype
EC50
30000±n/a nM
Comments
Extracted from aid = 2045 and tid = 2
Citation
PubChem, PC Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype PubChem Bioassay (2016)[AID] More Info.:
Target
Name:
Ras-related protein Rab-2A
Synonyms:
RAB2 | RAB2A | RAB2A_CANLF | Ras-related protein Rab-2A.
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23545.28
Organism:
Canis lupus familiaris
Description:
gi_46577642
Residue:
212
Sequence:
MAYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGKQIKLQIWDTAGQESFRSITRSYYRGAAGALLVYDITRRDTFNHLTTWLEDARQHSNSNMVIMLIGNKSDLESRREVKKEEGEAFAREHGLIFMETSAKTASNVEEAFINTAKEIYEKIQEGVFDINNEANGIKIGPQHAATNATHAGNQGGQQAGGGCC
Inhibitor
Name:
BDBM54656
Synonyms:
4-[3-(4-methoxyphenyl)-5-(4-methylphenyl)-3,4-dihydropyrazol-2-yl]benzenesulfonamide | 4-[5-(4-methoxyphenyl)-3-(p-tolyl)-2-pyrazolin-1-yl]benzenesulfonamide | KUC103418N | UNM-0000306154 | cid_15201821
Type:
Small organic molecule
Emp. Form.:
C23H23N3O3S
Mol. Mass.:
421.512
SMILES:
COc1ccc(cc1)C1CC(=NN1c1ccc(cc1)S(N)(=O)=O)c1ccc(C)cc1 |c:11|
Structure:
