Reaction Details Report a problem with these data
Target
Ras-related protein Rab-2A
Ligand
BDBM54679
Substrate
n/a
Meas. Tech.
Additional SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype
EC50
30000±n/a nM
Citation
 PubChem, PC Additional SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype PubChem Bioassay (2009)[AID] 
Target
Name:
Ras-related protein Rab-2A
Synonyms:
RAB2 | RAB2A | RAB2A_CANLF | Ras-related protein Rab-2A.
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23545.28
Organism:
Canis lupus familiaris
Description:
gi_46577642
Residue:
212
Sequence:
MAYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGKQIKLQIWDTAGQESFRSITRSYYRGAAGALLVYDITRRDTFNHLTTWLEDARQHSNSNMVIMLIGNKSDLESRREVKKEEGEAFAREHGLIFMETSAKTASNVEEAFINTAKEIYEKIQEGVFDINNEANGIKIGPQHAATNATHAGNQGGQQAGGGCC
  
Inhibitor
Name:
BDBM54679
Synonyms:
(3E)-4-bromanyl-3-(3-oxidanylidene-1H-inden-2-ylidene)-1H-indol-2-one | (3E)-4-bromo-3-(1-ketoindan-2-ylidene)oxindole | (3E)-4-bromo-3-(3-oxo-1H-inden-2-ylidene)-1H-indol-2-one | UNM-0000305765 | cid_25220926
Type:
Small organic molecule
Emp. Form.:
C17H10BrNO2
Mol. Mass.:
340.171
SMILES:
Brc1cccc2NC(=O)\C(=C3/Cc4ccccc4C3=O)c12
Structure:
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