Reaction Details Report a problem with these data
Target
Ras-related protein Rab-2A
Ligand
BDBM54686
Substrate
n/a
Meas. Tech.
Additional SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype
EC50
30000±n/a nM
Citation
 PubChem, PC Additional SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype PubChem Bioassay (2009)[AID] 
Target
Name:
Ras-related protein Rab-2A
Synonyms:
RAB2 | RAB2A | RAB2A_CANLF | Ras-related protein Rab-2A.
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23545.28
Organism:
Canis lupus familiaris
Description:
gi_46577642
Residue:
212
Sequence:
MAYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGKQIKLQIWDTAGQESFRSITRSYYRGAAGALLVYDITRRDTFNHLTTWLEDARQHSNSNMVIMLIGNKSDLESRREVKKEEGEAFAREHGLIFMETSAKTASNVEEAFINTAKEIYEKIQEGVFDINNEANGIKIGPQHAATNATHAGNQGGQQAGGGCC
  
Inhibitor
Name:
BDBM54686
Synonyms:
2-amino-5-benzoyl-4-(3-bromo-4-methoxy-phenyl)-1-mesyl-pyrrole-3-carbonitrile | 2-amino-5-benzoyl-4-(3-bromo-4-methoxyphenyl)-1-methylsulfonyl-3-pyrrolecarbonitrile | 2-amino-5-benzoyl-4-(3-bromo-4-methoxyphenyl)-1-methylsulfonylpyrrole-3-carbonitrile | 2-azanyl-4-(3-bromanyl-4-methoxy-phenyl)-1-methylsulfonyl-5-(phenylcarbonyl)pyrrole-3-carbonitrile | UNM-0000305776 | cid_25220927
Type:
Small organic molecule
Emp. Form.:
C20H16BrN3O4S
Mol. Mass.:
474.328
SMILES:
COc1ccc(cc1Br)-c1c(C#N)c(N)n(c1C(=O)c1ccccc1)S(C)(=O)=O
Structure:
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