Reaction Details Report a problem with these data
Target
GTPase KRas [1-37]
Ligand
BDBM54658
Substrate
n/a
Meas. Tech.
Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype
EC50
30000±n/a nM
Citation
 PubChem, PC Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype PubChem Bioassay (2009)[AID] 
Target
Name:
GTPase KRas [1-37]
Synonyms:
ras protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
4034.04
Organism:
Homo sapiens (Human)
Description:
gi_190938
Residue:
37
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIE
  
Inhibitor
Name:
BDBM54658
Synonyms:
4-[3-(4-methoxyphenyl)-5-[4-(trifluoromethyl)phenyl]-3,4-dihydropyrazol-2-yl]benzenesulfonamide | 4-[5-(4-methoxyphenyl)-3-[4-(trifluoromethyl)phenyl]-2-pyrazolin-1-yl]benzenesulfonamide | KUC103437N | UNM-0000306156 | cid_44143711
Type:
Small organic molecule
Emp. Form.:
C23H20F3N3O3S
Mol. Mass.:
475.483
SMILES:
COc1ccc(cc1)C1CC(=NN1c1ccc(cc1)S(N)(=O)=O)c1ccc(cc1)C(F)(F)F |c:11|
Structure:
Search PDB for entries with ligand similarity: