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Target
Ras-related C3 botulinum toxin substrate 1
Ligand
BDBM54543
Substrate
n/a
Meas. Tech.
Oxadiazole SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac1 activated mutant
EC50
9795±n/a nM
Citation
 PubChem, PC Oxadiazole SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac1 activated mutant PubChem Bioassay (2009)[AID] 
Target
Name:
Ras-related C3 botulinum toxin substrate 1
Synonyms:
RAC1_MOUSE | Rac1 | Rac1 protein
Type:
PROTEIN
Mol. Mass.:
21455.91
Organism:
Mus musculus
Description:
EBI_101485
Residue:
192
Sequence:
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL
  
Inhibitor
Name:
BDBM54543
Synonyms:
3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-[4-(3-methoxyphenyl)-1-piperazinyl]-1-propanone | 3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-[4-(3-methoxyphenyl)piperazin-1-yl]propan-1-one | 3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-[4-(3-methoxyphenyl)piperazino]propan-1-one | KUC103349N | UNM-0000306063 | cid_25241701
Type:
Small organic molecule
Emp. Form.:
C23H26N4O4
Mol. Mass.:
422.4769
SMILES:
COc1ccc(cc1)-c1noc(CCC(=O)N2CCN(CC2)c2cccc(OC)c2)n1
Structure:
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