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Target
Amyloid-beta A4 precursor protein-binding family A member 1
Ligand
BDBM33191
Substrate
n/a
Meas. Tech.
uHTS Homogeneous Terbium Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay
IC50
7130±n/a nM
Citation
 PubChem, PC uHTS Homogeneous Terbium Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay PubChem Bioassay (2009)[AID] 
Target
Name:
Amyloid-beta A4 precursor protein-binding family A member 1
Synonyms:
APBA1_RAT | Apba1 | Mint1 | X11 | neuronal munc18-1 binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
92603.32
Organism:
Rattus norvegicus
Description:
gi_2625023
Residue:
839
Sequence:
MNHLEGSAEVEVADEAPGGEVNESVEADLEHPEVEEEQQPSPPPPAGHAPEDHRAHPAPPPPPPPQEEEEERGECLARSASTESGFHNHTDTAEGDVLAAARDGYEAERAQDADDESAYAVQYRPEAEEYTEQAEAEHAEAAQRRALPNHLHFHSLEHEEAMNAAYSGYVYTHRLFHRAEDEPYAEPYADYGGLQEHVYEEIGDAPELEARDGLRLYERERDEAAAYRQEALGARLHHYDERSDGESDSPEKEAEFAPYPRMDSYEQEEDIDQIVAEVKQSMSSQSLDKAAEDMPEAEQDLERAPTPGGGHPDSPGLPAPAGQQQRVVGTPGGSEVGQRYSKEKRDAISLAIKDIKEAIEEVKTRTIRSPYTPDEPKEPIWVMRQDISPTRDCDDQRPVDGDSPSPGSSSPLGAESSITPLHPGDPTEASTNKESRKSLASFPTYVEVPGPCDPEDLIDGIIFAANYLGSTQLLSDKTPSKNVRMMQAQEAVSRIKTAQKLAKSRKKAPEGESQPMTEVDLFISTQRIKVLNADTQEPMMDHPLRTISYIADIGNIVVLMARRRMPRSNSQENVEASHPSQDAKRQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQKEYSDLLNTQDMYNDDLIHFSKSENCKDVFIEKQKGEILGVVIVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVRCPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATPHEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVYI
  
Inhibitor
Name:
BDBM33191
Synonyms:
4-[(4-chloro-5-dithiazolylidene)amino]benzoic acid ethyl ester | 4-[(4-chlorodithiazol-5-ylidene)amino]benzoic acid ethyl ester | MLS000763689 | SMR000334029 | cid_2769040 | ethyl 4-[(4-chloranyl-1,2,3-dithiazol-5-ylidene)amino]benzoate | ethyl 4-[(4-chloro-5H-1,2,3-dithiazol-5-yliden)amino]benzenecarboxylate | ethyl 4-[(4-chlorodithiazol-5-ylidene)amino]benzoate
Type:
Small organic molecule
Emp. Form.:
C11H9ClN2O2S2
Mol. Mass.:
300.784
SMILES:
CCOC(=O)c1ccc(cc1)\N=c1\ssnc1Cl
Structure:
Search PDB for entries with ligand similarity: