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Target
Amyloid-beta A4 precursor protein-binding family A member 1
Ligand
BDBM52875
Substrate
n/a
Meas. Tech.
uHTS Homogeneous Terbium Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay
IC50
10300±n/a nM
Citation
 PubChem, PC uHTS Homogeneous Terbium Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay PubChem Bioassay (2009)[AID] 
Target
Name:
Amyloid-beta A4 precursor protein-binding family A member 1
Synonyms:
APBA1_RAT | Apba1 | Mint1 | X11 | neuronal munc18-1 binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
92603.32
Organism:
Rattus norvegicus
Description:
gi_2625023
Residue:
839
Sequence:
MNHLEGSAEVEVADEAPGGEVNESVEADLEHPEVEEEQQPSPPPPAGHAPEDHRAHPAPPPPPPPQEEEEERGECLARSASTESGFHNHTDTAEGDVLAAARDGYEAERAQDADDESAYAVQYRPEAEEYTEQAEAEHAEAAQRRALPNHLHFHSLEHEEAMNAAYSGYVYTHRLFHRAEDEPYAEPYADYGGLQEHVYEEIGDAPELEARDGLRLYERERDEAAAYRQEALGARLHHYDERSDGESDSPEKEAEFAPYPRMDSYEQEEDIDQIVAEVKQSMSSQSLDKAAEDMPEAEQDLERAPTPGGGHPDSPGLPAPAGQQQRVVGTPGGSEVGQRYSKEKRDAISLAIKDIKEAIEEVKTRTIRSPYTPDEPKEPIWVMRQDISPTRDCDDQRPVDGDSPSPGSSSPLGAESSITPLHPGDPTEASTNKESRKSLASFPTYVEVPGPCDPEDLIDGIIFAANYLGSTQLLSDKTPSKNVRMMQAQEAVSRIKTAQKLAKSRKKAPEGESQPMTEVDLFISTQRIKVLNADTQEPMMDHPLRTISYIADIGNIVVLMARRRMPRSNSQENVEASHPSQDAKRQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQKEYSDLLNTQDMYNDDLIHFSKSENCKDVFIEKQKGEILGVVIVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVRCPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATPHEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVYI
  
Inhibitor
Name:
BDBM52875
Synonyms:
(5E)-1-(4-methoxyphenyl)-5-[(5-nitro-2-thienyl)methylene]barbituric acid | (5Z)-1-(4-methoxyphenyl)-5-[(5-nitro-2-thienyl)methylene]barbituric acid | (5Z)-1-(4-methoxyphenyl)-5-[(5-nitro-2-thiophenyl)methylidene]-1,3-diazinane-2,4,6-trione | (5Z)-1-(4-methoxyphenyl)-5-[(5-nitrothiophen-2-yl)methylidene]-1,3-diazinane-2,4,6-trione | 1-(4-Methoxy-phenyl)-5-[1-(5-nitro-thiophen-2-yl)-meth-(Z)-ylidene]-pyrimidine-2,4,6-trione | MLS000768292 | SMR000431613 | cid_1907064
Type:
Small organic molecule
Emp. Form.:
C16H11N3O6S
Mol. Mass.:
373.34
SMILES:
COc1ccc(cc1)-n1c(=O)[nH]c([O-])c([CH+]c2ccc(s2)[N+]([O-])=O)c1=O
Structure:
Search PDB for entries with ligand similarity: