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Target
Amyloid-beta A4 precursor protein-binding family A member 1
Ligand
BDBM50620
Substrate
n/a
Meas. Tech.
uHTS Homogeneous Terbium Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay
IC50
2150±n/a nM
Citation
 PubChem, PC uHTS Homogeneous Terbium Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay PubChem Bioassay (2009)[AID] 
Target
Name:
Amyloid-beta A4 precursor protein-binding family A member 1
Synonyms:
APBA1_RAT | Apba1 | Mint1 | X11 | neuronal munc18-1 binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
92603.32
Organism:
Rattus norvegicus
Description:
gi_2625023
Residue:
839
Sequence:
MNHLEGSAEVEVADEAPGGEVNESVEADLEHPEVEEEQQPSPPPPAGHAPEDHRAHPAPPPPPPPQEEEEERGECLARSASTESGFHNHTDTAEGDVLAAARDGYEAERAQDADDESAYAVQYRPEAEEYTEQAEAEHAEAAQRRALPNHLHFHSLEHEEAMNAAYSGYVYTHRLFHRAEDEPYAEPYADYGGLQEHVYEEIGDAPELEARDGLRLYERERDEAAAYRQEALGARLHHYDERSDGESDSPEKEAEFAPYPRMDSYEQEEDIDQIVAEVKQSMSSQSLDKAAEDMPEAEQDLERAPTPGGGHPDSPGLPAPAGQQQRVVGTPGGSEVGQRYSKEKRDAISLAIKDIKEAIEEVKTRTIRSPYTPDEPKEPIWVMRQDISPTRDCDDQRPVDGDSPSPGSSSPLGAESSITPLHPGDPTEASTNKESRKSLASFPTYVEVPGPCDPEDLIDGIIFAANYLGSTQLLSDKTPSKNVRMMQAQEAVSRIKTAQKLAKSRKKAPEGESQPMTEVDLFISTQRIKVLNADTQEPMMDHPLRTISYIADIGNIVVLMARRRMPRSNSQENVEASHPSQDAKRQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQKEYSDLLNTQDMYNDDLIHFSKSENCKDVFIEKQKGEILGVVIVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVRCPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATPHEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVYI
  
Inhibitor
Name:
BDBM50620
Synonyms:
2-(2-furanyl)-4-quinolinecarboxylic acid [2-[(1,1-dioxo-3-thiolanyl)-methylamino]-2-oxoethyl] ester | 2-(2-furyl)cinchoninic acid [2-[(1,1-diketothiolan-3-yl)-methyl-amino]-2-keto-ethyl] ester | MLS000772718 | SMR000377370 | [2-[(1,1-dioxothiolan-3-yl)-methylamino]-2-oxoethyl] 2-(furan-2-yl)quinoline-4-carboxylate | [2-[[1,1-bis(oxidanylidene)thiolan-3-yl]-methyl-amino]-2-oxidanylidene-ethyl] 2-(furan-2-yl)quinoline-4-carboxylate | cid_4008175
Type:
Small organic molecule
Emp. Form.:
C21H20N2O6S
Mol. Mass.:
428.458
SMILES:
CN(C1CCS(=O)(=O)C1)C(=O)COC(=O)c1cc(nc2ccccc12)-c1ccco1
Structure:
Search PDB for entries with ligand similarity: