Target
Amyloid-beta A4 precursor protein-binding family A member 1
Ligand
BDBM54757
Substrate
n/a
Meas. Tech.
uHTS Homogeneous Terbium Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay
IC50
6790±n/a nM
Citation
 PubChem, PC uHTS Homogeneous Terbium Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay PubChem Bioassay (2009)[AID] 
Target
Name:
Amyloid-beta A4 precursor protein-binding family A member 1
Synonyms:
APBA1_RAT | Apba1 | Mint1 | X11 | neuronal munc18-1 binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
92603.32
Organism:
Rattus norvegicus
Description:
gi_2625023
Residue:
839
Sequence:
MNHLEGSAEVEVADEAPGGEVNESVEADLEHPEVEEEQQPSPPPPAGHAPEDHRAHPAPPPPPPPQEEEEERGECLARSASTESGFHNHTDTAEGDVLAAARDGYEAERAQDADDESAYAVQYRPEAEEYTEQAEAEHAEAAQRRALPNHLHFHSLEHEEAMNAAYSGYVYTHRLFHRAEDEPYAEPYADYGGLQEHVYEEIGDAPELEARDGLRLYERERDEAAAYRQEALGARLHHYDERSDGESDSPEKEAEFAPYPRMDSYEQEEDIDQIVAEVKQSMSSQSLDKAAEDMPEAEQDLERAPTPGGGHPDSPGLPAPAGQQQRVVGTPGGSEVGQRYSKEKRDAISLAIKDIKEAIEEVKTRTIRSPYTPDEPKEPIWVMRQDISPTRDCDDQRPVDGDSPSPGSSSPLGAESSITPLHPGDPTEASTNKESRKSLASFPTYVEVPGPCDPEDLIDGIIFAANYLGSTQLLSDKTPSKNVRMMQAQEAVSRIKTAQKLAKSRKKAPEGESQPMTEVDLFISTQRIKVLNADTQEPMMDHPLRTISYIADIGNIVVLMARRRMPRSNSQENVEASHPSQDAKRQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQKEYSDLLNTQDMYNDDLIHFSKSENCKDVFIEKQKGEILGVVIVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVRCPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATPHEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVYI
  
Inhibitor
Name:
BDBM54757
Synonyms:
(8R)-7-[(E)-1-oxobut-2-enyl]-3-[3-[[(2Z,4E)-1-oxohexa-2,4-dienyl]amino]phenyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide | (8R)-7-[(E)-but-2-enoyl]-3-[3-[[(2Z,4E)-hexa-2,4-dienoyl]amino]phenyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide | MLS000562027 | SMR000390738 | cid_16745470
Type:
Small organic molecule
Emp. Form.:
C23H26N4O4
Mol. Mass.:
422.4769
SMILES:
C\C=C\C=C/C(=O)Nc1cccc(c1)C1=NOC2(C[C@@H](N(C2)C(=O)\C=C\C)C(N)=O)C1 |t:15|
Structure:
Search PDB for entries with ligand similarity: