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Target
Kappa-type opioid receptor
Ligand
BDBM54819
Substrate
n/a
Meas. Tech.
HTS Image-Based Screen for Selective Antagonists of the KOR Receptor
IC50
4021±492 nM
Citation
 PubChem, PC HTS Image-Based Screen for Selective Antagonists of the KOR Receptor PubChem Bioassay (2009)[AID] 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM54819
Synonyms:
1-(4-tert-butylphenyl)-4-chloranyl-6-oxidanylidene-pyridazine-3-carbonitrile | 1-(4-tert-butylphenyl)-4-chloro-6-keto-pyridazine-3-carbonitrile | 1-(4-tert-butylphenyl)-4-chloro-6-oxo-3-pyridazinecarbonitrile | 1-(4-tert-butylphenyl)-4-chloro-6-oxopyridazine-3-carbonitrile | 1-[4-(tert-butyl)phenyl]-4-chloro-6-oxo-1,6-dihydro-3-pyridazinecarbonitrile | MLS000763752 | SMR000334094 | cid_2766929
Type:
Small organic molecule
Emp. Form.:
C15H14ClN3O
Mol. Mass.:
287.744
SMILES:
CC(C)(C)c1ccc(cc1)-n1nc(C#N)c(Cl)cc1=O
Structure:
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