Reaction Details Report a problem with these data
Target
Kappa-type opioid receptor
Ligand
BDBM54820
Substrate
n/a
Meas. Tech.
HTS Image-Based Screen for Selective Antagonists of the KOR Receptor
IC50
14021±3070 nM
Citation
 PubChem, PC HTS Image-Based Screen for Selective Antagonists of the KOR Receptor PubChem Bioassay (2009)[AID] 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM54820
Synonyms:
4-chloranyl-1-(4-methoxyphenyl)-6-oxidanylidene-pyridazine-3-carbonitrile | 4-chloro-1-(4-methoxyphenyl)-6-oxo-1,6-dihydro-3-pyridazinecarbonitrile | 4-chloro-1-(4-methoxyphenyl)-6-oxo-3-pyridazinecarbonitrile | 4-chloro-1-(4-methoxyphenyl)-6-oxopyridazine-3-carbonitrile | 4-chloro-6-keto-1-(4-methoxyphenyl)pyridazine-3-carbonitrile | MLS000696258 | SMR000333378 | cid_3775913
Type:
Small organic molecule
Emp. Form.:
C12H8ClN3O2
Mol. Mass.:
261.664
SMILES:
COc1ccc(cc1)-n1nc(C#N)c(Cl)cc1=O
Structure:
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