Reaction Details Report a problem with these data
Target
Streptokinase A
Ligand
BDBM54856
Substrate
n/a
Meas. Tech.
Absorbance Microorganism-Based Dose Response Followup to Identify Inhibitors of Streptokinase Expression
EC50
5898±1039 nM
Citation
 PubChem, PC Absorbance Microorganism-Based Dose Response Followup to Identify Inhibitors of Streptokinase Expression PubChem Bioassay (2009)[AID] 
Target
Name:
Streptokinase A
Synonyms:
STRP_STRP1 | ska | streptokinase A precursor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49924.80
Organism:
Streptococcus pyogenes M1 GAS
Description:
gi_15675770
Residue:
440
Sequence:
MKNYLSIGVIALLFALTFGTVKSVQAIAGYGWLPDRPPINNSQLVVSMAGIVEGTDKKVFINFFEIDLTSQPAHGGKTEQGLSPKSKPFATDNGAMPHKLEKADLLKAIQKQLIANVHSNDGYFEVIDFASDATITDRNGKVYFADKDGSVTLPTQPVQEFLLKGHVRVRPYKEKPVQNQAKSVDVEYTVQFTPLNPDDDFRPGLKDTKLLKTLAIGDTITSQELLAQAQSILNKTHPGYTIYERDSSIVTHDNDIFRTILPMDQEFTYHVKNREQAYEINPKTGIKEKTNNTDLVSEKYYVLKQGEKPYDPFDRSHLKLFTIKYVDVNTNELLKSEQLLTASERNLDFRDLYDPRDKAKLLYNNLDAFDIMDYTLTGKVEDNHDKNNRVVTVYMGKRPKGAKGSYHLAYDKDLYTEEERKAYSYLRDTGTPIPDNPKDK
  
Inhibitor
Name:
BDBM54856
Synonyms:
7-[(4-chlorophenyl)methyl]-1,3-dimethyl-8-(phenylmethylsulfanyl)purine-2,6-dione | 7-[(4-chlorophenyl)methyl]-1,3-dimethyl-8-(phenylmethylthio)purine-2,6-dione | 8-(benzylthio)-7-(4-chlorobenzyl)-1,3-dimethyl-xanthine | 8-benzylsulfanyl-7-[(4-chlorophenyl)methyl]-1,3-dimethylpurine-2,6-dione | BRD-K03108423-001-04-4 | cid_1102623
Type:
Small organic molecule
Emp. Form.:
C21H19ClN4O2S
Mol. Mass.:
426.919
SMILES:
Cn1c2nc(SCc3ccccc3)n(Cc3ccc(Cl)cc3)c2c(=O)n(C)c1=O
Structure:
Search PDB for entries with ligand similarity: