Reaction Details Report a problem with these data
Target
Streptokinase A
Ligand
BDBM54877
Substrate
n/a
Meas. Tech.
Absorbance Microorganism-Based Dose Response Followup to Identify Inhibitors of Streptokinase Expression
EC50
4003±1058 nM
Citation
 PubChem, PC Absorbance Microorganism-Based Dose Response Followup to Identify Inhibitors of Streptokinase Expression PubChem Bioassay (2009)[AID] 
Target
Name:
Streptokinase A
Synonyms:
STRP_STRP1 | ska | streptokinase A precursor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49924.80
Organism:
Streptococcus pyogenes M1 GAS
Description:
gi_15675770
Residue:
440
Sequence:
MKNYLSIGVIALLFALTFGTVKSVQAIAGYGWLPDRPPINNSQLVVSMAGIVEGTDKKVFINFFEIDLTSQPAHGGKTEQGLSPKSKPFATDNGAMPHKLEKADLLKAIQKQLIANVHSNDGYFEVIDFASDATITDRNGKVYFADKDGSVTLPTQPVQEFLLKGHVRVRPYKEKPVQNQAKSVDVEYTVQFTPLNPDDDFRPGLKDTKLLKTLAIGDTITSQELLAQAQSILNKTHPGYTIYERDSSIVTHDNDIFRTILPMDQEFTYHVKNREQAYEINPKTGIKEKTNNTDLVSEKYYVLKQGEKPYDPFDRSHLKLFTIKYVDVNTNELLKSEQLLTASERNLDFRDLYDPRDKAKLLYNNLDAFDIMDYTLTGKVEDNHDKNNRVVTVYMGKRPKGAKGSYHLAYDKDLYTEEERKAYSYLRDTGTPIPDNPKDK
  
Inhibitor
Name:
BDBM54877
Synonyms:
BRD-K49130511-001-04-7 | N-[5-[(4-chlorophenyl)sulfamoyl]-2-(1-piperidinyl)phenyl]-4-fluorobenzamide | N-[5-[(4-chlorophenyl)sulfamoyl]-2-piperidin-1-yl-phenyl]-4-fluoranyl-benzamide | N-[5-[(4-chlorophenyl)sulfamoyl]-2-piperidin-1-ylphenyl]-4-fluorobenzamide | N-[5-[(4-chlorophenyl)sulfamoyl]-2-piperidino-phenyl]-4-fluoro-benzamide | cid_4604044
Type:
Small organic molecule
Emp. Form.:
C24H23ClFN3O3S
Mol. Mass.:
487.974
SMILES:
Fc1ccc(cc1)C(=O)Nc1cc(ccc1N1CCCCC1)S(=O)(=O)Nc1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: