Reaction Details Report a problem with these data
Target
Streptokinase A
Ligand
BDBM54886
Substrate
n/a
Meas. Tech.
Absorbance Microorganism-Based Dose Response Followup to Identify Inhibitors of Streptokinase Expression
EC50
12553±1169 nM
Citation
 PubChem, PC Absorbance Microorganism-Based Dose Response Followup to Identify Inhibitors of Streptokinase Expression PubChem Bioassay (2009)[AID] 
Target
Name:
Streptokinase A
Synonyms:
STRP_STRP1 | ska | streptokinase A precursor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49924.80
Organism:
Streptococcus pyogenes M1 GAS
Description:
gi_15675770
Residue:
440
Sequence:
MKNYLSIGVIALLFALTFGTVKSVQAIAGYGWLPDRPPINNSQLVVSMAGIVEGTDKKVFINFFEIDLTSQPAHGGKTEQGLSPKSKPFATDNGAMPHKLEKADLLKAIQKQLIANVHSNDGYFEVIDFASDATITDRNGKVYFADKDGSVTLPTQPVQEFLLKGHVRVRPYKEKPVQNQAKSVDVEYTVQFTPLNPDDDFRPGLKDTKLLKTLAIGDTITSQELLAQAQSILNKTHPGYTIYERDSSIVTHDNDIFRTILPMDQEFTYHVKNREQAYEINPKTGIKEKTNNTDLVSEKYYVLKQGEKPYDPFDRSHLKLFTIKYVDVNTNELLKSEQLLTASERNLDFRDLYDPRDKAKLLYNNLDAFDIMDYTLTGKVEDNHDKNNRVVTVYMGKRPKGAKGSYHLAYDKDLYTEEERKAYSYLRDTGTPIPDNPKDK
  
Inhibitor
Name:
BDBM54886
Synonyms:
1-(5-chloranyl-2-ethoxy-phenyl)sulfonyl-5,6-dimethyl-benzimidazole | 1-(5-chloro-2-ethoxy-phenyl)sulfonyl-5,6-dimethyl-benzimidazole | 1-(5-chloro-2-ethoxyphenyl)sulfonyl-5,6-dimethylbenzimidazole | BRD-K69226362-001-05-5 | cid_1288960
Type:
Small organic molecule
Emp. Form.:
C17H17ClN2O3S
Mol. Mass.:
364.846
SMILES:
CCOc1ccc(Cl)cc1S(=O)(=O)n1cnc2cc(C)c(C)cc12
Structure:
Search PDB for entries with ligand similarity: