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Target
Genome polyprotein
Ligand
BDBM55078
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay for inhibitors of the Hepatitis C Virus non-structural protein 3 helicase (NS3).
IC50
2644±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay for inhibitors of the Hepatitis C Virus non-structural protein 3 helicase (NS3). PubChem Bioassay (2009)[AID] 
Target
Name:
Genome polyprotein
Synonyms:
NS3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
67067.41
Organism:
Hepatitis C virus
Description:
gi_125541954
Residue:
631
Sequence:
APITAYAQQTRGLLGCIITGLTGRDKNQVEGEVQIVSTAAQTFLATCINGVCWTVYHGAGTRTIASSKGPVIQMYTNVDQDLVGWPAPQGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDGRGSLLSPRPISYLKGSSGGPLLCPAGHAVGIFRAAVCTRGVAKAVDFIPVEGLETTMRSPVFSDNSSPPAVPQSYQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGIDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGSAYDIIICDECHSTDATSILGIGTVLDQAETAGARLTVLATATPPGSVTVPHPNIEEVALSTTGEIPFYGKAIPLEAIKGGRHLIFCHSKKKCDELAAKLVALGVNAVAYYRGLDVSVIPASGDVVVVATDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVTPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHIDAHFLSQTKQSGENLPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEITLTHPITKYIMTCMSADLEVVT
  
Inhibitor
Name:
BDBM55078
Synonyms:
3-(furan-2-carbonyl)-4-hydroxy-1-(5-methyl-1,2-oxazol-3-yl)-2-(3-phenoxyphenyl)-2H-pyrrol-5-one | 3-(furan-2-ylcarbonyl)-1-(5-methyl-1,2-oxazol-3-yl)-4-oxidanyl-2-(3-phenoxyphenyl)-2H-pyrrol-5-one | 3-[2-furanyl(oxo)methyl]-4-hydroxy-1-(5-methyl-3-isoxazolyl)-2-(3-phenoxyphenyl)-2H-pyrrol-5-one | 4-(2-furoyl)-3-hydroxy-1-(5-methylisoxazol-3-yl)-5-(3-phenoxyphenyl)-3-pyrrolin-2-one | MLS001142547 | SMR000647895 | cid_4308410
Type:
Small organic molecule
Emp. Form.:
C25H18N2O6
Mol. Mass.:
442.4202
SMILES:
Cc1cc(no1)N1C(C(C(=O)c2ccco2)C(=O)C1=O)c1cccc(Oc2ccccc2)c1
Structure:
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