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Target
Metabotropic glutamate receptor 4 [Q124R]
Ligand
BDBM55088
Substrate
n/a
Meas. Tech.
Modulation of the Metabotropic Glutamate Receptor mGluR4: Rat PAM Potency
EC50
650±n/a nM
Citation
 PubChem, PC Modulation of the Metabotropic Glutamate Receptor mGluR4: Rat PAM Potency PubChem Bioassay (2010)[AID] 
Target
Name:
Metabotropic glutamate receptor 4 [Q124R]
Synonyms:
GRM4_RAT | Gprc1d | Grm4 | Mglur4 | glutamate receptor, metabotropic 4 precursor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
101878.86
Organism:
Rattus norvegicus
Description:
gi_12083595
Residue:
912
Sequence:
MSGKGGWAWWWARLPLCLLLSLYAPWVPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKACGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVRALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTLASEGSYGESGVEAFIQKSRENGGVCIAQSVKIPREPKTGEFDKIIKRLLETSNARGIIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKSAPVLRLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHIKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNGSAEYKVIGSWTDHLHLRIERMQWPGSGQQLPRSICSLPCQPGERKKTVKGMACCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTSCQPIPIVKLEWDSPWAVLPLFLAVVGIAATLFVVVTFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFILISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLETPALATKQTYVTYTNHAI
  
Inhibitor
Name:
BDBM55088
Synonyms:
N-[4-[(7aS)-1,3-bis(oxidanylidene)-3a,4,5,6,7,7a-hexahydroisoindol-2-yl]-3-chloranyl-phenyl]pyridine-2-carboxamide | N-[4-[(7aS)-1,3-diketo-3a,4,5,6,7,7a-hexahydroisoindol-2-yl]-3-chloro-phenyl]picolinamide | N-[4-[(7aS)-1,3-dioxo-3a,4,5,6,7,7a-hexahydroisoindol-2-yl]-3-chlorophenyl]-2-pyridinecarboxamide | N-[4-[(7aS)-1,3-dioxo-3a,4,5,6,7,7a-hexahydroisoindol-2-yl]-3-chlorophenyl]pyridine-2-carboxamide | VU0366515-1 | cid_46869945
Type:
Small organic molecule
Emp. Form.:
C20H18ClN3O3
Mol. Mass.:
383.828
SMILES:
Oc1c2CCCCc2c(O)n1-c1ccc(NC(=O)c2ccccn2)cc1Cl |(7.68,2.7,;7.2,1.24,;5.75,.77,;4.41,1.54,;3.08,.77,;3.08,-.77,;4.41,-1.54,;5.75,-.77,;7.2,-1.24,;7.68,-2.7,;8.1,,;9.64,,;10.41,1.33,;11.95,1.33,;12.72,,;14.26,,;15.03,1.33,;14.26,2.67,;16.57,1.33,;17.34,2.67,;18.88,2.67,;19.65,1.33,;18.88,,;17.34,,;11.95,-1.33,;10.41,-1.33,;9.64,-2.67,)|
Structure:
Search PDB for entries with ligand similarity: