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Target
M18 aspartyl aminopeptidase
Ligand
BDBM55098
Substrate
n/a
Meas. Tech.
QFRET-based biochemical high throughput dose response assay for inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP).
IC50
350.49±n/a nM
Citation
 PubChem, PC QFRET-based biochemical high throughput dose response assay for inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). PubChem Bioassay (2009)[AID] 
Target
Name:
M18 aspartyl aminopeptidase
Synonyms:
n/a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
65642.43
Organism:
Plasmodium falciparum 3D7
Description:
gi_23505220
Residue:
570
Sequence:
MDKKAREYAQDALKFIQRSGSNFLACKNLKERLENNGFINLSEGETWNLNKNEGYVLCKENRNICGFFVGKNFNIDTGSILISIGHIDSCALKISPNNNVIKKKIHQINVECYGSGLWHTWFDRSLGLSGQVLYKKGNKLVEKLIQINKSVLFLPSLAIHLQNRTRYDFSVKINYENHIKPIISTTLFNQLNKCKRNNVHHDTILTTDTKFSHKENSQNKRDDQMCHSFNDKDVSNHNLDKNTIEHLTNQQNEEKNKHTKDNPNSKDIVEHINTDNSYPLLYLLSKELNCKEEDILDFELCLMDTQEPCFTGVYEEFIEGARFDNLLGSFCVFEGFIELVNSIKNHTSNENTNHTNNITNDINDNIHNNLYISIGYDHEEIGSLSEVGARSYCTKNFIDRIISSVFKKEIHEKNLSVQEIYGNLVNRSFILNVDMAHCSHPNYPETVQDNHQLFFHEGIAIKYNTNKNYVTSPLHASLIKRTFELYYNKYKQQIKYQNFMVKNDTPCGSTVGSMVAANLSMPGIDIGIPQLAMHSIREIAAVHDVFFLIKGVFAFYTYYNQVLSTCVHDK
  
Inhibitor
Name:
BDBM55098
Synonyms:
(1,3-dioxoisoindol-2-yl)methyl 2-(1H-1,2,4-triazol-5-ylsulfanyl)acetate | (2H-[1,2,4]Triazol-3-ylsulfanyl)-acetic acid 1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl ester | 2-(1H-1,2,4-triazol-5-ylthio)acetic acid (1,3-dioxo-2-isoindolyl)methyl ester | 2-(1H-1,2,4-triazol-5-ylthio)acetic acid phthalimidomethyl ester | MLS000031579 | SMR000010622 | [1,3-bis(oxidanylidene)isoindol-2-yl]methyl 2-(1H-1,2,4-triazol-5-ylsulfanyl)ethanoate | cid_650854
Type:
Small organic molecule
Emp. Form.:
C13H10N4O4S
Mol. Mass.:
318.308
SMILES:
O=C(CSc1nnc[nH]1)OCN1C(=O)c2ccccc2C1=O
Structure:
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