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Target
M18 aspartyl aminopeptidase
Ligand
BDBM53205
Substrate
n/a
Meas. Tech.
QFRET-based biochemical high throughput dose response assay for inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP).
IC50
2787±n/a nM
Citation
 PubChem, PC QFRET-based biochemical high throughput dose response assay for inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). PubChem Bioassay (2009)[AID] 
Target
Name:
M18 aspartyl aminopeptidase
Synonyms:
n/a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
65642.43
Organism:
Plasmodium falciparum 3D7
Description:
gi_23505220
Residue:
570
Sequence:
MDKKAREYAQDALKFIQRSGSNFLACKNLKERLENNGFINLSEGETWNLNKNEGYVLCKENRNICGFFVGKNFNIDTGSILISIGHIDSCALKISPNNNVIKKKIHQINVECYGSGLWHTWFDRSLGLSGQVLYKKGNKLVEKLIQINKSVLFLPSLAIHLQNRTRYDFSVKINYENHIKPIISTTLFNQLNKCKRNNVHHDTILTTDTKFSHKENSQNKRDDQMCHSFNDKDVSNHNLDKNTIEHLTNQQNEEKNKHTKDNPNSKDIVEHINTDNSYPLLYLLSKELNCKEEDILDFELCLMDTQEPCFTGVYEEFIEGARFDNLLGSFCVFEGFIELVNSIKNHTSNENTNHTNNITNDINDNIHNNLYISIGYDHEEIGSLSEVGARSYCTKNFIDRIISSVFKKEIHEKNLSVQEIYGNLVNRSFILNVDMAHCSHPNYPETVQDNHQLFFHEGIAIKYNTNKNYVTSPLHASLIKRTFELYYNKYKQQIKYQNFMVKNDTPCGSTVGSMVAANLSMPGIDIGIPQLAMHSIREIAAVHDVFFLIKGVFAFYTYYNQVLSTCVHDK
  
Inhibitor
Name:
BDBM53205
Synonyms:
1,3-bis[[(Z)-(3-hydroxy-4-keto-cyclohexa-2,5-dien-1-ylidene)methyl]amino]urea | 1,3-bis[[(Z)-(3-hydroxy-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]amino]urea | 1,3-bis[[(Z)-(3-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]amino]urea | 1,3-bis[[(Z)-(3-oxidanyl-4-oxidanylidene-cyclohexa-2,5-dien-1-ylidene)methyl]amino]urea | MLS001202140 | N'',N'''-bis[(1E)-(3,4-dihydroxyphenyl)methylene]carbonohydrazide | SMR000565039 | cid_24762014
Type:
Small organic molecule
Emp. Form.:
C15H14N4O5
Mol. Mass.:
330.2955
SMILES:
O=C(NN=CC1=CC(=O)C(=O)CC1)NN=CC1=CC(=O)C(=O)CC1 |w:3.2,14.14,t:5,17|
Structure:
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