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Target
Procathepsin L
Ligand
BDBM55138
Substrate
n/a
Meas. Tech.
QFRET-based counterscreen for inhibitors of PFM18AAP: biochemical high throughput dose response assay for inhibitors of the Cathepsin L proteinase (CTSL1).
IC50
>59642±n/a nM
Citation
 PubChem, PC QFRET-based counterscreen for inhibitors of PFM18AAP: biochemical high throughput dose response assay for inhibitors of the Cathepsin L proteinase (CTSL1). PubChem Bioassay (2009)[AID] 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM55138
Synonyms:
(6E)-4-bromanyl-6-[[(5-tert-butyl-2-oxidanyl-phenyl)amino]methylidene]cyclohexa-2,4-dien-1-one | (6E)-4-bromo-6-[(5-tert-butyl-2-hydroxy-anilino)methylene]cyclohexa-2,4-dien-1-one | (6E)-4-bromo-6-[(5-tert-butyl-2-hydroxyanilino)methylidene]-1-cyclohexa-2,4-dienone | (6E)-4-bromo-6-[(5-tert-butyl-2-hydroxyanilino)methylidene]cyclohexa-2,4-dien-1-one | MLS000714154 | SMR000274134 | cid_5409880
Type:
Small organic molecule
Emp. Form.:
C17H18BrNO2
Mol. Mass.:
348.234
SMILES:
CC(C)(C)c1ccc(O)c(c1)N=Cc1cc(Br)ccc1O |w:11.11|
Structure:
Search PDB for entries with ligand similarity: