Reaction Details Report a problem with these data
Target
Procathepsin L
Ligand
BDBM55158
Substrate
n/a
Meas. Tech.
QFRET-based counterscreen for inhibitors of PFM18AAP: biochemical high throughput dose response assay for inhibitors of the Cathepsin L proteinase (CTSL1).
IC50
>59642±n/a nM
Citation
 PubChem, PC QFRET-based counterscreen for inhibitors of PFM18AAP: biochemical high throughput dose response assay for inhibitors of the Cathepsin L proteinase (CTSL1). PubChem Bioassay (2009)[AID] 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM55158
Synonyms:
(4Z)-2-hydroxy-4-[(1,2,4-triazol-1-ylamino)methylene]cyclohexa-2,5-dien-1-one | (4Z)-2-hydroxy-4-[(1,2,4-triazol-1-ylamino)methylidene]-1-cyclohexa-2,5-dienone | (4Z)-2-hydroxy-4-[(1,2,4-triazol-1-ylamino)methylidene]cyclohexa-2,5-dien-1-one | (4Z)-2-oxidanyl-4-[(1,2,4-triazol-1-ylamino)methylidene]cyclohexa-2,5-dien-1-one | 4-[(E)-(1H-1,2,4-triazol-1-ylimino)methyl]benzene-1,2-diol | MLS001194928 | SMR000554660 | cid_23734016
Type:
Small organic molecule
Emp. Form.:
C9H8N4O2
Mol. Mass.:
204.1854
SMILES:
Oc1ccc(C=Nn2cncn2)cc1O |w:6.6|
Structure:
Search PDB for entries with ligand similarity: