Reaction Details Report a problem with these data
Target
Alkaline phosphatase, germ cell type
Ligand
BDBM39611
Substrate
n/a
Meas. Tech.
Luminescent assay for HTS discovery of chemical activators of placental alkaline phosphatase
EC50
2650±n/a nM
Citation
 PubChem, PC Luminescent assay for HTS discovery of chemical activators of placental alkaline phosphatase PubChem Bioassay (2007)[AID] 
Target
Name:
Alkaline phosphatase, germ cell type
Synonyms:
ALPG | ALPPL | ALPPL2 | Alkaline phosphatase placental-like | PPBN_HUMAN | placental-like alkaline phosphatase preproprotein
Type:
PROTEIN
Mol. Mass.:
57374.31
Organism:
Homo sapiens (Human)
Description:
ChEMBL_29964
Residue:
532
Sequence:
MQGPWVLLLLGLRLQLSLGIIPVEEENPDFWNRQAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPETFLAMDRFPYVALSKTYSVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGAYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKHQGARYVWNRTELLQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALLLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDGETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPRAGTTDAAHPGPSVVPALLPLLAGTLLLLGTATAP
  
Inhibitor
Name:
BDBM39611
Synonyms:
1-(2-keto-2-pyrrolidino-ethyl)-3-phenyl-thieno[3,2-d]pyrimidine-2,4-quinone | 1-(2-oxidanylidene-2-pyrrolidin-1-yl-ethyl)-3-phenyl-thieno[3,2-d]pyrimidine-2,4-dione | 1-(2-oxo-2-pyrrolidin-1-ylethyl)-3-phenylthieno[3,2-d]pyrimidine-2,4(1H,3H)-dione | 1-(2-oxo-2-pyrrolidin-1-ylethyl)-3-phenylthieno[3,2-d]pyrimidine-2,4-dione | 1-[2-oxo-2-(1-pyrrolidinyl)ethyl]-3-phenylthieno[3,2-d]pyrimidine-2,4-dione | MLS000087515 | SMR000023738 | cid_3236980
Type:
Small organic molecule
Emp. Form.:
C18H17N3O3S
Mol. Mass.:
355.411
SMILES:
O=C(Cn1c2ccsc2c(=O)n(-c2ccccc2)c1=O)N1CCCC1
Structure:
Search PDB for entries with ligand similarity: