Reaction Details Report a problem with these data
Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM59271
Substrate
n/a
Meas. Tech.
uHTS identification of compounds activating TNAP in the absence of phosphate acceptor performed in luminescent assay
EC50
43482±n/a nM
Citation
 PubChem, PC uHTS identification of compounds activating TNAP in the absence of phosphate acceptor performed in luminescent assay PubChem Bioassay (2009)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM59271
Synonyms:
1-[[2-(2-hydroxypropyl)-5-methyl-1-oxohexyl]amino]-3-prop-2-enylthiourea | 1-[[2-(2-hydroxypropyl)-5-methylhexanoyl]amino]-3-prop-2-enylthiourea | 1-[[5-methyl-2-(2-oxidanylpropyl)hexanoyl]amino]-3-prop-2-enyl-thiourea | 1-allyl-3-[[2-(2-hydroxypropyl)-5-methyl-hexanoyl]amino]thiourea | MLS000552570 | SMR000146085 | cid_3278571
Type:
Small organic molecule
Emp. Form.:
C14H27N3O2S
Mol. Mass.:
301.448
SMILES:
CC(C)CCC(CC(C)O)C(=O)NNC(=S)NCC=C
Structure:
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