Reaction Details Report a problem with these data
Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM59284
Substrate
n/a
Meas. Tech.
uHTS identification of compounds activating TNAP in the absence of phosphate acceptor performed in luminescent assay
EC50
79464±n/a nM
Citation
 PubChem, PC uHTS identification of compounds activating TNAP in the absence of phosphate acceptor performed in luminescent assay PubChem Bioassay (2009)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM59284
Synonyms:
MLS000556175 | N'-[2-(6-methoxy-2-methyl-quinolin-4-yl)sulfanylethanoyl]-2-phenoxy-ethanehydrazide | N'-[2-(6-methoxy-2-methylquinolin-4-yl)sulfanylacetyl]-2-phenoxyacetohydrazide | N'-[2-[(6-methoxy-2-methyl-4-quinolinyl)thio]-1-oxoethyl]-2-phenoxyacetohydrazide | N'-[2-[(6-methoxy-2-methyl-4-quinolyl)thio]acetyl]-2-phenoxy-acetohydrazide | Phenoxy-acetic acid N'-[2-(6-methoxy-2-methyl-quinolin-4-ylsulfanyl)-acetyl]-hydrazide | SMR000172541 | cid_3168483
Type:
Small organic molecule
Emp. Form.:
C21H21N3O4S
Mol. Mass.:
411.474
SMILES:
COc1ccc2nc(C)cc(SCC(=O)NNC(=O)COc3ccccc3)c2c1
Structure:
Search PDB for entries with ligand similarity: