Reaction Details Report a problem with these data
Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM59319
Substrate
n/a
Meas. Tech.
uHTS identification of compounds activating TNAP in the absence of phosphate acceptor performed in luminescent assay
EC50
100000±n/a nM
Citation
 PubChem, PC uHTS identification of compounds activating TNAP in the absence of phosphate acceptor performed in luminescent assay PubChem Bioassay (2009)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM59319
Synonyms:
(2-methoxy-4-morpholin-4-ylcarbothioyl-phenyl) (E)-3-(furan-2-yl)prop-2-enoate | (E)-3-(2-furanyl)-2-propenoic acid [2-methoxy-4-[4-morpholinyl(sulfanylidene)methyl]phenyl] ester | (E)-3-(2-furyl)acrylic acid [2-methoxy-4-(morpholine-4-carbothioyl)phenyl] ester | 2-methoxy-4-(morpholin-4-ylcarbonothioyl)phenyl (2E)-3-(2-furyl)acrylate | MLS000728095 | SMR000306788 | [2-methoxy-4-(morpholine-4-carbothioyl)phenyl] (E)-3-(furan-2-yl)prop-2-enoate | cid_1514461
Type:
Small organic molecule
Emp. Form.:
C19H19NO5S
Mol. Mass.:
373.423
SMILES:
COc1cc(ccc1OC(=O)\C=C\c1ccco1)C(=S)N1CCOCC1
Structure:
Search PDB for entries with ligand similarity: