Reaction Details Report a problem with these data
Target
M17 leucyl aminopeptidase
Ligand
BDBM59695
Substrate
n/a
Meas. Tech.
Inhibitors of Plasmodium falciparum M17- Family Leucine Aminopeptidase (M17LAP)
IC50
1470±n/a nM
Citation
 PubChem, PC Inhibitors of Plasmodium falciparum M17- Family Leucine Aminopeptidase (M17LAP) PubChem Bioassay (2009)[AID] 
Target
Name:
M17 leucyl aminopeptidase
Synonyms:
leucine aminopeptidase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
67834.32
Organism:
Plasmodium falciparum 3D7
Description:
gi_124809582
Residue:
605
Sequence:
MYFSSLCKFLPISEKEKIYLNIVKKRFCKSNIYYNNNNNNIINYNKRGLKFYPFCNNLKKNINFVNINNKKGINFHSINKERKMASEVPQVVSLDPTSIPIEYNTPIHDIKVQVYDIKGGCNVEEGLTIFLVNNPGKENGPVKISSKVNDKNVSEFLKDENMEKFNVKLGTSKHFYMFNDNKNSVAVGYVGCGSVADLSEADMKRVVLSLVTMLHDNKLSKLTVVFEINVDKNLFRFFLETLFYEYMTDERFKSTDKNVNMEYIKHLGVYINNADTYKEEVEKARVYYFGTYYASQLIAAPSNYCNPVSLSNAAVELAQKLNLEYKILGVKELEELKMGAYLSVGKGSMYPNKFIHLTYKSKGDVKKKIALVGKGITFDSGGYNLKAAPGSMIDLMKFDMSGCAAVLGCAYCVGTLKPENVEIHFLSAVCENMVSKNSYRPGDIITASNGKTIEVGNTDAEGRLTLADALVYAEKLGVDYIVDIATLTGAMLYSLGTSYAGVFGNNEELINKILNSSKTSNEPVWWLPIINEYRATLNSKYADINNISSSVKASSIVASLFLKEFVQNTAWAHIDIAGVSWNFKARKPKGFGVRLLTEFVLNDAL
  
Inhibitor
Name:
BDBM59695
Synonyms:
MLS000051170 | N-(3-cyano-4,5-diphenyl-2-furanyl)-2-(4-oxo-3-quinazolinyl)acetamide | N-(3-cyano-4,5-diphenyl-2-furyl)-2-(4-ketoquinazolin-3-yl)acetamide | N-(3-cyano-4,5-diphenyl-2-furyl)-2-(4-oxo-3(4H)-quinazolinyl)acetamide | N-(3-cyano-4,5-diphenyl-furan-2-yl)-2-(4-oxidanylidenequinazolin-3-yl)ethanamide | N-(3-cyano-4,5-diphenylfuran-2-yl)-2-(4-oxoquinazolin-3-yl)acetamide | SMR000079100 | cid_2220151
Type:
Small organic molecule
Emp. Form.:
C27H18N4O3
Mol. Mass.:
446.4568
SMILES:
O=C(Cn1cnc2ccccc2c1=O)Nc1oc(c(c1C#N)-c1ccccc1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: