Reaction Details Report a problem with these data
Target
M17 leucyl aminopeptidase
Ligand
BDBM50372
Substrate
n/a
Meas. Tech.
Inhibitors of Plasmodium falciparum M17- Family Leucine Aminopeptidase (M17LAP)
IC50
1000±n/a nM
Citation
 PubChem, PC Inhibitors of Plasmodium falciparum M17- Family Leucine Aminopeptidase (M17LAP) PubChem Bioassay (2009)[AID] 
Target
Name:
M17 leucyl aminopeptidase
Synonyms:
leucine aminopeptidase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
67834.32
Organism:
Plasmodium falciparum 3D7
Description:
gi_124809582
Residue:
605
Sequence:
MYFSSLCKFLPISEKEKIYLNIVKKRFCKSNIYYNNNNNNIINYNKRGLKFYPFCNNLKKNINFVNINNKKGINFHSINKERKMASEVPQVVSLDPTSIPIEYNTPIHDIKVQVYDIKGGCNVEEGLTIFLVNNPGKENGPVKISSKVNDKNVSEFLKDENMEKFNVKLGTSKHFYMFNDNKNSVAVGYVGCGSVADLSEADMKRVVLSLVTMLHDNKLSKLTVVFEINVDKNLFRFFLETLFYEYMTDERFKSTDKNVNMEYIKHLGVYINNADTYKEEVEKARVYYFGTYYASQLIAAPSNYCNPVSLSNAAVELAQKLNLEYKILGVKELEELKMGAYLSVGKGSMYPNKFIHLTYKSKGDVKKKIALVGKGITFDSGGYNLKAAPGSMIDLMKFDMSGCAAVLGCAYCVGTLKPENVEIHFLSAVCENMVSKNSYRPGDIITASNGKTIEVGNTDAEGRLTLADALVYAEKLGVDYIVDIATLTGAMLYSLGTSYAGVFGNNEELINKILNSSKTSNEPVWWLPIINEYRATLNSKYADINNISSSVKASSIVASLFLKEFVQNTAWAHIDIAGVSWNFKARKPKGFGVRLLTEFVLNDAL
  
Inhibitor
Name:
BDBM50372
Synonyms:
3-[(N''E)-N''-(4-allyloxy-2,3-dibromo-5-methoxy-benzylidene)hydrazino]benzoic acid | 3-[(N'E)-N'-(4-allyloxy-2,3-dibromo-5-methoxy-benzylidene)hydrazino]benzoic acid | 3-[2-[(2,3-dibromo-5-methoxy-4-prop-2-enoxyphenyl)methylidene]hydrazinyl]benzoic acid | 3-[2-[[2,3-bis(bromanyl)-5-methoxy-4-prop-2-enoxy-phenyl]methylidene]hydrazinyl]benzoic acid | 3-[N'-(4-allyloxy-2,3-dibromo-5-methoxy-benzylidene)hydrazino]benzoic acid | 3-{2-[4-(allyloxy)-2,3-dibromo-5-methoxybenzylidene]hydrazino}benzoic acid | MLS000700860 | SMR000231284 | cid_3333662
Type:
Small organic molecule
Emp. Form.:
C18H16Br2N2O4
Mol. Mass.:
484.139
SMILES:
COc1cc(CN=Nc2cccc(c2)C(O)=O)c(Br)c(Br)c1OCC=C |w:7.7|
Structure:
Search PDB for entries with ligand similarity: