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Target
SUMO-activating enzyme subunit 1
Ligand
BDBM61215
Substrate
n/a
Meas. Tech.
uHTS HTRF assay for identification of inhibitors of SUMOylation
IC50
9220±n/a nM
Citation
 PubChem, PC uHTS HTRF assay for identification of inhibitors of SUMOylation PubChem Bioassay (2010)[AID] 
Target
Name:
SUMO-activating enzyme subunit 1
Synonyms:
AOS1 | SAE1 | SAE1_HUMAN | SUA1 | SUMO-activating enzyme subunit 1 (SAE1) | SUMO1 activating enzyme subunit 1 | UBLE1A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38440.84
Organism:
Homo sapiens (Human)
Description:
gi_17390638
Residue:
346
Sequence:
MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTKVAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDYFLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK
  
Inhibitor
Name:
BDBM61215
Synonyms:
(5-amino-1-naphthalenyl)arsonic acid | (5-amino-1-naphthyl)arsonic acid | (5-aminonaphthalen-1-yl)arsonic acid | (5-azanylnaphthalen-1-yl)arsonic acid | MLS000737441 | SMR000528143 | cid_224922
Type:
Small organic molecule
Emp. Form.:
C10H10AsNO3
Mol. Mass.:
267.1129
SMILES:
Nc1cccc2c(cccc12)[As](O)(O)=O
Structure:
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