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Target
SUMO-activating enzyme subunit 1
Ligand
BDBM61247
Substrate
n/a
Meas. Tech.
uHTS HTRF assay for identification of inhibitors of SUMOylation
IC50
4470±n/a nM
Citation
 PubChem, PC uHTS HTRF assay for identification of inhibitors of SUMOylation PubChem Bioassay (2010)[AID] 
Target
Name:
SUMO-activating enzyme subunit 1
Synonyms:
AOS1 | SAE1 | SAE1_HUMAN | SUA1 | SUMO-activating enzyme subunit 1 (SAE1) | SUMO1 activating enzyme subunit 1 | UBLE1A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38440.84
Organism:
Homo sapiens (Human)
Description:
gi_17390638
Residue:
346
Sequence:
MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTKVAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDYFLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK
  
Inhibitor
Name:
BDBM61247
Synonyms:
2-azanylidene-3-(4-chlorophenyl)sulfonyl-1-(furan-2-ylmethyl)dipyrido[1,2-d:3',4'-f]pyrimidin-5-one | 3-(4-chlorophenyl)sulfonyl-1-(2-furanylmethyl)-2-imino-5-dipyrido[1,2-d:3',4'-f]pyrimidinone | 3-(4-chlorophenyl)sulfonyl-1-(2-furfuryl)-2-imino-dipyrido[1,2-d:3',4'-f]pyrimidin-5-one | 3-(4-chlorophenyl)sulfonyl-1-(furan-2-ylmethyl)-2-iminodipyrido[1,2-d:3',4'-f]pyrimidin-5-one | MLS000948072 | SMR000620258 | cid_3705648
Type:
Small organic molecule
Emp. Form.:
C22H15ClN4O4S
Mol. Mass.:
466.897
SMILES:
Clc1ccc(cc1)S(=O)(=O)c1cc2c(nc3ccccn3c2=O)n(Cc2ccco2)c1=N
Structure:
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