Reaction Details Report a problem with these data
Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM61263
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H)
IC50
58030±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2009)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM61263
Synonyms:
2-furancarboxylic acid [1-(2-furanylmethylamino)-3-methyl-1-oxobutan-2-yl] ester | Furan-2-carboxylic acid 1-[(furan-2-ylmethyl)-carbamoyl]-2-methyl-propyl ester | MLS000033367 | SMR000006550 | [1-(furan-2-ylmethylamino)-3-methyl-1-oxidanylidene-butan-2-yl] furan-2-carboxylate | [1-(furan-2-ylmethylamino)-3-methyl-1-oxobutan-2-yl] furan-2-carboxylate | cid_651361 | furan-2-carboxylic acid [1-(2-furfurylcarbamoyl)-2-methyl-propyl] ester
Type:
Small organic molecule
Emp. Form.:
C15H17NO5
Mol. Mass.:
291.2992
SMILES:
CC(C)C(OC(=O)c1ccco1)C(=O)NCc1ccco1
Structure:
Search PDB for entries with ligand similarity: