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Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM61274
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H)
IC50
13100±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2009)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM61274
Synonyms:
MLS000058276 | N-(2-furfurylcarbamoyl)-2-[4-[(E)-styryl]sulfonylpiperazino]acetamide | N-(furan-2-ylmethylcarbamoyl)-2-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]acetamide | N-(furan-2-ylmethylcarbamoyl)-2-[4-[(E)-2-phenylethenyl]sulfonylpiperazin-1-yl]ethanamide | N-[(2-furanylmethylamino)-oxomethyl]-2-[4-[(E)-2-phenylethenyl]sulfonyl-1-piperazinyl]acetamide | SMR000065278 | cid_2698138
Type:
Small organic molecule
Emp. Form.:
C20H24N4O5S
Mol. Mass.:
432.493
SMILES:
O=C(CN1CCN(CC1)S(=O)(=O)\C=C\c1ccccc1)NC(=O)NCc1ccco1
Structure:
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