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Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM50137
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H)
IC50
23575±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2009)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM50137
Synonyms:
MLS000560945 | N-[[(E)-3-(2-furyl)-1-methyl-prop-2-enylidene]amino]-2-(2-thienyl)acetamide | N-[[(E)-4-(2-furanyl)but-3-en-2-ylidene]amino]-2-thiophen-2-ylacetamide | N-[[(E)-4-(furan-2-yl)but-3-en-2-ylidene]amino]-2-thiophen-2-yl-ethanamide | N-[[(E)-4-(furan-2-yl)but-3-en-2-ylidene]amino]-2-thiophen-2-ylacetamide | SMR000175287 | Thiophen-2-yl-acetic acid (3-furan-2-yl-1-methyl-allylidene)-hydrazide | cid_739483
Type:
Small organic molecule
Emp. Form.:
C14H14N2O2S
Mol. Mass.:
274.338
SMILES:
CC(C=Cc1ccco1)=NNC(=O)Cc1cccs1 |w:9.10,2.1|
Structure:
Search PDB for entries with ligand similarity: