Reaction Details Report a problem with these data
Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM61288
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H)
IC50
21940±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2009)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM61288
Synonyms:
(E)-3-(2-furanyl)-2-propenoic acid [2-[3-(dimethylsulfamoyl)-4-methylanilino]-2-oxoethyl] ester | (E)-3-(2-furyl)acrylic acid [2-[3-(dimethylsulfamoyl)-4-methyl-anilino]-2-keto-ethyl] ester | MLS000393664 | SMR000241408 | [2-[3-(dimethylsulfamoyl)-4-methylanilino]-2-oxoethyl] (E)-3-(furan-2-yl)prop-2-enoate | [2-[[3-(dimethylsulfamoyl)-4-methyl-phenyl]amino]-2-oxidanylidene-ethyl] (E)-3-(furan-2-yl)prop-2-enoate | cid_5968624
Type:
Small organic molecule
Emp. Form.:
C18H20N2O6S
Mol. Mass.:
392.426
SMILES:
CN(C)S(=O)(=O)c1cc(NC(=O)COC(=O)\C=C\c2ccco2)ccc1C
Structure:
Search PDB for entries with ligand similarity: