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Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM61297
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H)
IC50
100000±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2009)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM61297
Synonyms:
(8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl) furan-2-carboxylate;bromide | 2-furancarboxylic acid (8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl) ester;bromide | 3-(2-furoyloxy)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane | MLS000766743 | SMR000339639 | cid_16195126 | furan-2-carboxylic acid (8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl) ester;bromide
Type:
Small organic molecule
Emp. Form.:
C14H20NO3
Mol. Mass.:
250.313
SMILES:
[H]C12CCC([H])(CC(C1)OC(=O)c1ccco1)[N+]2(C)C
Structure:
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