Reaction Details Report a problem with these data
Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM51289
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H)
IC50
11490±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2009)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM51289
Synonyms:
5-Thiophen-2-yl-2H-pyrazole-3-carboxylic acid [2-oxo-1,2-dihydro-indol-(3Z)-ylidene]-hydrazide | MLS000807030 | N'-(2-ketoindol-3-yl)-5-(2-thienyl)-1H-pyrazole-3-carbohydrazide | N'-(2-oxidanylideneindol-3-yl)-5-thiophen-2-yl-1H-pyrazole-3-carbohydrazide | N'-(2-oxo-3-indolyl)-5-thiophen-2-yl-1H-pyrazole-3-carbohydrazide | N'-(2-oxoindol-3-yl)-5-thiophen-2-yl-1H-pyrazole-3-carbohydrazide | SMR000414789 | cid_5422293
Type:
Small organic molecule
Emp. Form.:
C16H11N5O2S
Mol. Mass.:
337.356
SMILES:
O=C(NNC1=c2ccccc2=NC1=O)c1cc(n[nH]1)-c1cccs1 |c:4,11|
Structure:
Search PDB for entries with ligand similarity: