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Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM61324
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H)
IC50
100000±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2009)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM61324
Synonyms:
MLS001008067 | N-(6-bromanyl-1,3-diethyl-2-oxidanylidene-benzimidazol-5-yl)-2-phenyl-propanamide | N-(6-bromo-1,3-diethyl-2-keto-benzimidazol-5-yl)-2-phenyl-propionamide | N-(6-bromo-1,3-diethyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-2-phenylpropanamide | N-(6-bromo-1,3-diethyl-2-oxo-5-benzimidazolyl)-2-phenylpropanamide | N-(6-bromo-1,3-diethyl-2-oxobenzimidazol-5-yl)-2-phenylpropanamide | SMR000498304 | cid_2972939
Type:
Small organic molecule
Emp. Form.:
C20H22BrN3O2
Mol. Mass.:
416.312
SMILES:
CCn1c2cc(Br)c(NC(=O)C(C)c3ccccc3)cc2n(CC)c1=O
Structure:
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