Reaction Details Report a problem with these data
Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM61380
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H)
IC50
100000±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2009)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM61380
Synonyms:
MLS001034740 | N-(4-ethylphenyl)-4-methyl-3-(morpholine-4-carbonyl)benzenesulfonamide | N-(4-ethylphenyl)-4-methyl-3-[4-morpholinyl(oxo)methyl]benzenesulfonamide | N-(4-ethylphenyl)-4-methyl-3-morpholin-4-ylcarbonyl-benzenesulfonamide | SMR000670793 | cid_6462016
Type:
Small organic molecule
Emp. Form.:
C20H24N2O4S
Mol. Mass.:
388.481
SMILES:
CCc1ccc(NS(=O)(=O)c2ccc(C)c(c2)C(=O)N2CCOCC2)cc1
Structure:
Search PDB for entries with ligand similarity: