Reaction Details Report a problem with these data
Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM61385
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H)
IC50
100000±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2009)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM61385
Synonyms:
2-chloranyl-N-[4-(diethylcarbamoyl)phenyl]-5-(4-ethylpiperazin-1-yl)sulfonyl-benzamide | 2-chloro-N-[4-(diethylcarbamoyl)phenyl]-5-(4-ethylpiperazin-1-yl)sulfonylbenzamide | 2-chloro-N-[4-(diethylcarbamoyl)phenyl]-5-(4-ethylpiperazino)sulfonyl-benzamide | 2-chloro-N-[4-[diethylamino(oxo)methyl]phenyl]-5-[(4-ethyl-1-piperazinyl)sulfonyl]benzamide | MLS001141999 | SMR000688237 | cid_24818057
Type:
Small organic molecule
Emp. Form.:
C24H31ClN4O4S
Mol. Mass.:
507.045
SMILES:
CCN(CC)C(=O)c1ccc(NC(=O)c2cc(ccc2Cl)S(=O)(=O)N2CCN(CC)CC2)cc1
Structure:
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