Reaction Details Report a problem with these data
Target
Polyadenylate-binding protein 1
Ligand
BDBM61265
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP)
IC50
3290±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP) PubChem Bioassay (2009)[AID] 
Target
Name:
Polyadenylate-binding protein 1
Synonyms:
PAB1 | PABP | PABP1 | PABP1_HUMAN | PABPC1 | PABPC2 | poly(A) binding protein, cytoplasmic 1 | polyadenylate-binding protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70694.26
Organism:
Homo sapiens (Human)
Description:
gi_46367787
Residue:
636
Sequence:
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
  
Inhibitor
Name:
BDBM61265
Synonyms:
1-ethyl-3-(2-hydroxyethyl)-2-methyl-5-benzimidazol-1-iumcarboxylic acid ethyl ester;iodide | 1-ethyl-3-(2-hydroxyethyl)-2-methyl-benzimidazol-1-ium-5-carboxylic acid ethyl ester;iodide | 6-Ethoxycarbonyl-3-ethyl-1-(2-hydroxy-ethyl)-2-methyl-3H-benzoimidazol-1-ium | MLS000029721 | SMR000000974 | cid_654505 | ethyl 1-ethyl-3-(2-hydroxyethyl)-2-methyl-benzimidazol-1-ium-5-carboxylate;iodide | ethyl 1-ethyl-3-(2-hydroxyethyl)-2-methylbenzimidazol-1-ium-5-carboxylate;iodide
Type:
Small organic molecule
Emp. Form.:
C15H21N2O3
Mol. Mass.:
277.3383
SMILES:
CCOC(=O)c1ccc2[n+](CC)c(C)n(CCO)c2c1
Structure:
Search PDB for entries with ligand similarity: