Target
Polyadenylate-binding protein 1
Ligand
BDBM61284
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP)
IC50
100000±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP) PubChem Bioassay (2009)[AID] 
Target
Name:
Polyadenylate-binding protein 1
Synonyms:
PAB1 | PABP | PABP1 | PABP1_HUMAN | PABPC1 | PABPC2 | poly(A) binding protein, cytoplasmic 1 | polyadenylate-binding protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70694.26
Organism:
Homo sapiens (Human)
Description:
gi_46367787
Residue:
636
Sequence:
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
  
Inhibitor
Name:
BDBM61284
Synonyms:
(E)-2-(4-fluorophenyl)-3-(2-keto-1,3-dimethyl-benzimidazol-5-yl)acrylonitrile | (E)-3-(1,3-dimethyl-2-oxidanylidene-benzimidazol-5-yl)-2-(4-fluorophenyl)prop-2-enenitrile | (E)-3-(1,3-dimethyl-2-oxo-5-benzimidazolyl)-2-(4-fluorophenyl)-2-propenenitrile | (E)-3-(1,3-dimethyl-2-oxobenzimidazol-5-yl)-2-(4-fluorophenyl)prop-2-enenitrile | 3-(1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-2-(4-fluorophenyl)acrylonitrile | MLS000583231 | SMR000201065 | cid_1243673
Type:
Small organic molecule
Emp. Form.:
C18H14FN3O
Mol. Mass.:
307.3217
SMILES:
Cn1c2ccc(\C=C(\C#N)c3ccc(F)cc3)cc2n(C)c1=O
Structure:
Search PDB for entries with ligand similarity: