Reaction Details Report a problem with these data
Target
Polyadenylate-binding protein 1
Ligand
BDBM61316
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP)
IC50
9630±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP) PubChem Bioassay (2009)[AID] 
Target
Name:
Polyadenylate-binding protein 1
Synonyms:
PAB1 | PABP | PABP1 | PABP1_HUMAN | PABPC1 | PABPC2 | poly(A) binding protein, cytoplasmic 1 | polyadenylate-binding protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70694.26
Organism:
Homo sapiens (Human)
Description:
gi_46367787
Residue:
636
Sequence:
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
  
Inhibitor
Name:
BDBM61316
Synonyms:
(4-Hydroxy-4,4-diphenyl-but-2-ynyl)-isopropyl-dimethyl-ammonium | (4-hydroxy-4,4-diphenyl-but-2-ynyl)-isopropyl-dimethyl-ammonium;bromide | (4-hydroxy-4,4-diphenylbut-2-ynyl)-dimethyl-propan-2-ylammonium;bromide | (4-hydroxy-4,4-diphenylbut-2-ynyl)-dimethyl-propan-2-ylazanium;bromide | MLS000767808 | SMR000430137 | cid_16682506 | dimethyl-(4-oxidanyl-4,4-diphenyl-but-2-ynyl)-propan-2-yl-azanium;bromide
Type:
Small organic molecule
Emp. Form.:
C21H26NO
Mol. Mass.:
308.4367
SMILES:
CC(C)[N+](C)(C)CC#CC(O)(c1ccccc1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: