Reaction Details Report a problem with these data
Target
Polyadenylate-binding protein 1
Ligand
BDBM61364
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP)
IC50
11860±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP) PubChem Bioassay (2009)[AID] 
Target
Name:
Polyadenylate-binding protein 1
Synonyms:
PAB1 | PABP | PABP1 | PABP1_HUMAN | PABPC1 | PABPC2 | poly(A) binding protein, cytoplasmic 1 | polyadenylate-binding protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70694.26
Organism:
Homo sapiens (Human)
Description:
gi_46367787
Residue:
636
Sequence:
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
  
Inhibitor
Name:
BDBM61364
Synonyms:
(4R,5R,6R)-1-ethyl-6-methyl-4-phenyl-2-[(3,4,5-trimethoxybenzyl)amino]-5,6-dihydro-4H-pyrimidine-5-carboxylic acid methyl ester | (4R,5R,6R)-1-ethyl-6-methyl-4-phenyl-2-[(3,4,5-trimethoxyphenyl)methylamino]-5,6-dihydro-4H-pyrimidine-5-carboxylic acid methyl ester | MLS000829852 | SMR000671995 | cid_24789238 | methyl (4R,5R,6R)-1-ethyl-6-methyl-4-phenyl-2-[(3,4,5-trimethoxyphenyl)methylamino]-5,6-dihydro-4H-pyrimidine-5-carboxylate
Type:
Small organic molecule
Emp. Form.:
C25H33N3O5
Mol. Mass.:
455.5466
SMILES:
CCN1[C@H](C)[C@H]([C@@H](N=C1NCc1cc(OC)c(OC)c(OC)c1)c1ccccc1)C(=O)OC |c:7|
Structure:
Search PDB for entries with ligand similarity: