Reaction Details Report a problem with these data
Target
Polyadenylate-binding protein 1
Ligand
BDBM61368
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP)
IC50
18915±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP) PubChem Bioassay (2009)[AID] 
Target
Name:
Polyadenylate-binding protein 1
Synonyms:
PAB1 | PABP | PABP1 | PABP1_HUMAN | PABPC1 | PABPC2 | poly(A) binding protein, cytoplasmic 1 | polyadenylate-binding protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70694.26
Organism:
Homo sapiens (Human)
Description:
gi_46367787
Residue:
636
Sequence:
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
  
Inhibitor
Name:
BDBM61368
Synonyms:
(4S)-1-benzyl-2-(4-hydroxybutylamino)-6-methyl-4-phenethyl-4H-pyrimidine-5-carboxylic acid methyl ester | (4S)-2-(4-hydroxybutylamino)-6-methyl-4-(2-phenylethyl)-1-(phenylmethyl)-4H-pyrimidine-5-carboxylic acid methyl ester | MLS000829926 | SMR000672087 | cid_24789246 | methyl (4S)-1-benzyl-2-(4-hydroxybutylamino)-6-methyl-4-(2-phenylethyl)-4H-pyrimidine-5-carboxylate | methyl (4S)-6-methyl-2-(4-oxidanylbutylamino)-4-(2-phenylethyl)-1-(phenylmethyl)-4H-pyrimidine-5-carboxylate
Type:
Small organic molecule
Emp. Form.:
C26H33N3O3
Mol. Mass.:
435.5585
SMILES:
COC(=O)C1=C(C)N(Cc2ccccc2)C(NCCCCO)=N[C@H]1CCc1ccccc1 |c:4,22|
Structure:
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