Reaction Details Report a problem with these data
Target
Polyadenylate-binding protein 1
Ligand
BDBM61369
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP)
IC50
13395±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP) PubChem Bioassay (2009)[AID] 
Target
Name:
Polyadenylate-binding protein 1
Synonyms:
PAB1 | PABP | PABP1 | PABP1_HUMAN | PABPC1 | PABPC2 | poly(A) binding protein, cytoplasmic 1 | polyadenylate-binding protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70694.26
Organism:
Homo sapiens (Human)
Description:
gi_46367787
Residue:
636
Sequence:
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
  
Inhibitor
Name:
BDBM61369
Synonyms:
(4S)-1-ethyl-4-(3-fluorophenyl)-6-methyl-2-[2-(2-pyridinyl)ethylamino]-4H-pyrimidine-5-carboxylic acid methyl ester | (4S)-1-ethyl-4-(3-fluorophenyl)-6-methyl-2-[2-(2-pyridyl)ethylamino]-4H-pyrimidine-5-carboxylic acid methyl ester | MLS000829950 | SMR000672057 | cid_24789251 | methyl (4S)-1-ethyl-4-(3-fluorophenyl)-6-methyl-2-(2-pyridin-2-ylethylamino)-4H-pyrimidine-5-carboxylate
Type:
Small organic molecule
Emp. Form.:
C22H25FN4O2
Mol. Mass.:
396.4579
SMILES:
CCN1C(C)=C([C@@H](N=C1NCCc1ccccn1)c1cccc(F)c1)C(=O)OC |c:4,7|
Structure:
Search PDB for entries with ligand similarity: