Reaction Details Report a problem with these data
Target
Polyadenylate-binding protein 1
Ligand
BDBM61370
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP)
IC50
8005±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP) PubChem Bioassay (2009)[AID] 
Target
Name:
Polyadenylate-binding protein 1
Synonyms:
PAB1 | PABP | PABP1 | PABP1_HUMAN | PABPC1 | PABPC2 | poly(A) binding protein, cytoplasmic 1 | polyadenylate-binding protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70694.26
Organism:
Homo sapiens (Human)
Description:
gi_46367787
Residue:
636
Sequence:
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
  
Inhibitor
Name:
BDBM61370
Synonyms:
(4S)-1-(2-methoxyethyl)-6-methyl-4-phenyl-2-(3-propan-2-yloxypropylamino)-4H-pyrimidine-5-carboxylic acid methyl ester | (4S)-2-(3-isopropoxypropylamino)-1-(2-methoxyethyl)-6-methyl-4-phenyl-4H-pyrimidine-5-carboxylic acid methyl ester | MLS000829958 | SMR000672047 | cid_24789253 | methyl (4S)-1-(2-methoxyethyl)-6-methyl-4-phenyl-2-(3-propan-2-yloxypropylamino)-4H-pyrimidine-5-carboxylate
Type:
Small organic molecule
Emp. Form.:
C22H33N3O4
Mol. Mass.:
403.5151
SMILES:
COCCN1C(NCCCOC(C)C)=N[C@H](C(C(=O)OC)=C1C)c1ccccc1 |c:13,20|
Structure:
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