Reaction Details Report a problem with these data
Target
G-protein coupled receptor 35
Ligand
BDBM51717
Substrate
n/a
Meas. Tech.
Image-Based HTS for Selective Antagonists of GPR35
IC50
533.7809±n/a nM
Citation
 PubChem, PC Image-Based HTS for Selective Antagonists of GPR35 PubChem Bioassay (2010)[AID] 
Target
Name:
G-protein coupled receptor 35
Synonyms:
G protein-coupled receptor 35 | GPR35 | GPR35_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
34085.57
Organism:
Homo sapiens (Human)
Description:
gi_33695097
Residue:
309
Sequence:
MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA
  
Inhibitor
Name:
BDBM51717
Synonyms:
MLS000592000 | N-[2-[(E)-1-cyano-2-(3,4-dichlorophenyl)ethenyl]-4-(4-methylphenyl)-1,3-thiazol-5-yl]acetamide | N-[2-[(E)-1-cyano-2-(3,4-dichlorophenyl)ethenyl]-4-(4-methylphenyl)-1,3-thiazol-5-yl]ethanamide | N-[2-[(E)-1-cyano-2-(3,4-dichlorophenyl)ethenyl]-4-(4-methylphenyl)-5-thiazolyl]acetamide | N-[2-[(E)-1-cyano-2-(3,4-dichlorophenyl)vinyl]-4-(p-tolyl)thiazol-5-yl]acetamide | N-{2-[(E)-1-Cyano-2-(3,4-dichloro-phenyl)-vinyl]-4-p-tolyl-thiazol-5-yl}-acetamide | SMR000218612 | cid_5936070
Type:
Small organic molecule
Emp. Form.:
C21H15Cl2N3OS
Mol. Mass.:
428.334
SMILES:
CC(=O)Nc1sc(nc1-c1ccc(C)cc1)C(=C\c1ccc(Cl)c(Cl)c1)\C#N
Structure:
Search PDB for entries with ligand similarity: