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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50305825
Substrate
n/a
Meas. Tech.
Discovery of Novel Allosteric Modulators of the Muscarinic Receptor M5: Calcium Flux Assay
EC50
14570±n/a nM
Citation
 PubChem, PC Discovery of Novel Allosteric Modulators of the Muscarinic Receptor M5: Calcium Flux Assay PubChem Bioassay (2010)[AID] 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51390.46
Organism:
RAT
Description:
P08482
Residue:
460
Sequence:
MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50305825
Synonyms:
1-(biphenyl-4-ylmethyl)-6-(trifluoromethoxy)indoline-2,3-dione | CHEMBL595628 | cid_45281808
Type:
Small organic molecule
Emp. Form.:
C22H14F3NO3
Mol. Mass.:
397.3467
SMILES:
FC(F)(F)Oc1ccc2C(=O)C(=O)N(Cc3ccc(cc3)-c3ccccc3)c2c1
Structure:
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